When is the submission deadline?

Submissions are due August 6, 2026.

What is the budget for this RFP?

Settle estimates the budget at $15,000,000 – $50,000,000. The issuer has not published an official figure.

It was issued by Advanced Research Projects Agency For Health. The work is located in Washington, District of Columbia, United States.

Who is a good fit for this opportunity?

AI and data platform firm with biomedical or life sciences expertise. Experience building interoperable research or laboratory ecosystems. Capability in mechanistic modeling, digital twins, or computational biology. Past performance with federal research or healthcare agencies. Multidisciplinary team spanning AI, cloud architecture, and life sciences. Ability to coordinate validated laboratory networks and standardized data workflows.

Intelligent Generator of Research Program Services (Due August 6, 2026)

Overview

Healthcare Services, Wellness & Biotech

Washington, District of Columbia, United StatesPosted: May 7th, 2026Deadline: August 6th, 2026

Fit Score

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SUMMARY

The solicitation seeks services to support an AI-enabled biomedical research ecosystem designed to improve research efficiency and accelerate therapy development for complex diseases. Requirements include AI-driven experiment design, interoperable laboratory execution, and mechanistic digital twin models.

KEY REQUIREMENTS

Must be registered in the System for Award Management (SAM.gov) with a valid Unique Entity Identifier (UEI)
Must address all four Technical Areas (TA1, TA2, TA3, & TA4)
Must address all three Phases (Phase I, Phase II, and Phase III)
Must be a commercial entity, academic institution, or non-profit organization
Must not be a Federally Funded Research and Development Center (FFRDC) or government entity
Must not be a party to a malign foreign talent recruitment program (MFTRP)
Must not be a non-domestic entity organized under the laws of a covered foreign country
Must submit a single proposal led by one Principal Investigator under a single prime performer
Must include at least two TA4 laboratories in the proposal team

BUDGET

Estimate

$15,000,000 – $50,000,000

CONTRACT DURATION

60 months

TIMELINE

Solution Summaries due date: June 25th, 2026

Proposals due date: August 6th, 2026

CONTACTS

Primary procurement contact — name, title, email, and phone

Additional decision-makers and their departments

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Issuing Agency

Advanced Research Projects Agency For Health

Organization overview and procurement intelligence available on paid plans.

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DESCRIPTION

The government authority in Washington, DC is seeking services for an Intelligent Generator of Research program. The initiative is intended to address longstanding inefficiencies in research and accelerate the development of effective therapies for complex diseases through an AI-enabled, interoperable research ecosystem.

The program scope includes an AI orchestration layer capable of identifying knowledge gaps and designing optimal experiments, as well as an AI-enabled interface for interrogating mechanistic models and laboratory capabilities to generate proposed experiments. The envisioned ecosystem also includes a distributed marketplace of validated laboratories that can execute standardized protocols and return high-quality, reproducible data.

Additional elements of the requirement include a layered protocol architecture that allows qualified laboratories to perform the same experiment consistently, and modular, mechanistic, multiscale models of complex diseases. These digital twin models are intended to capture causal, time-dependent biological relationships and function as a shared memory layer for the broader research ecosystem.

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Frequently asked questions

When is the submission deadline?: Submissions are due August 6, 2026.
What is the budget for this RFP?: Settle estimates the budget at $15,000,000 – $50,000,000. The issuer has not published an official figure.
Who issued this RFP?: It was issued by Advanced Research Projects Agency For Health. The work is located in Washington, District of Columbia, United States.
Who is a good fit for this opportunity?: AI and data platform firm with biomedical or life sciences expertise
Experience building interoperable research or laboratory ecosystems
Capability in mechanistic modeling, digital twins, or computational biology
Past performance with federal research or healthcare agencies
Multidisciplinary team spanning AI, cloud architecture, and life sciences
Ability to coordinate validated laboratory networks and standardized data workflows

Analysis generated by Settle AI from the source RFP.

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